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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ITPA hydrolyses dITP to dIMP

dITP + H2O → PPi + dIMP + H+

Reactome: R-HSA-2509838
Compartment: cytosol
Rhea: RHEA:28343, RHEA:28434

Inputs

dITPCHEBI:61382, C10H11N4O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

PPiCHEBI:33019, HO7P2, cytosol
dIMPCHEBI:61194, C10H11N4O7P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

dITP diphosphatase activity of ITPA dimer [cytosol]EC 3.6.1.66

ITPA hydrolyses dITP to dIMP

Inputs

Outputs

Catalysed by

Literature