NTPDase2 hydrolyzes nucleoside triphosphates
ATP,GTP,CTP,ITP,UTP + H2O → ADP,GDP,CDP,IDP,UDP + Pi + H+
- Reactome
- R-HSA-8851089
- Compartment
- extracellular region · plasma membrane
Inputs
- ATP,GTP,CTP,ITP,UTPR-ALL-8936166, extracellular region
- H2OCHEBI:15377, H2O, extracellular region
Outputs
- ADP,GDP,CDP,IDP,UDPR-ALL-8851092, extracellular region
- PiCHEBI:43474, HO4P, extracellular region
- H+CHEBI:15378, H, extracellular region
Catalysed by
- ribonucleoside triphosphate phosphatase activity of NTPDase2:Ca2+,Mg2+ [plasma membrane]EC 3.6.1.15
Literature
- Functional expression of a cDNA encoding a human ecto-ATPase Br. J. Pharmacol., 1999
- Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme J. Biol. Chem., 2003
- Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes Eur. J. Biochem., 2003
- Complementary DNA cloning and sequencing of the chicken muscle ecto-ATPase. Homology with the lymphoid cell activation antigen CD39 J. Biol. Chem., 1997
- An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain Neuropharmacology, 1997
- Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation Blood, 2002