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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)

(d)CMP, TMP, (d)UMP + H2O → (d)C, T, (d)U + Pi

Reactome: R-HSA-109380
Compartment: cytosol
Rhea: RHEA:11081, RHEA:29368, RHEA:29364, RHEA:29360, RHEA:29356

Inputs

(d)CMP, TMP, (d)UMPR-ALL-500347, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

(d)C, T, (d)UR-ALL-500346, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

5'-nucleotidase activity of NT5C1A tetramer [cytosol]EC 3.1.3.5

Literature

Mammalian 5'-nucleotidases J Biol Chem, 2003
Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance J Biol Chem, 2001
The mechanism of adenosine formation in cells. Cloning of cytosolic 5'-nucleotidase-I J Biol Chem, 1999
Partial purification and properties of an AMP-specific soluble 5'-nucleotidase from pigeon heart Biochem J, 1990