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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP

H2O + 8-oxo-dGTP(4-) → 8-oxo-dGMP(2-) + H+ + PPi

Reactome: R-HSA-2395869
Compartment: cytosol
Rhea: RHEA:31576

Inputs

H2OCHEBI:15377, H2O, cytosol
8-oxo-dGTP(4-)CHEBI:77896, C10H12N5O14P3, cytosol

Outputs

8-oxo-dGMP(2-)CHEBI:63224, C10H12N5O8P, cytosol
H+CHEBI:15378, H, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity of NUDT15 [cytosol]EC 3.6.1.55; UniProt Q9NV35

Literature

Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides Biochem. Biophys. Res. Commun., 2003
Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2 J. Biol. Chem., 2012