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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NTPDase1 hydrolyzes nucleoside diphosphates

NDP + H2O → NMP + Pi + H+

Reactome: R-HSA-8850854
Compartment: plasma membrane · extracellular region
Rhea: RHEA:36800

Inputs

NDPCHEBI:57930, C5H8O10P2R, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Outputs

NMPCHEBI:58043, C5H8O7PR, extracellular region
PiCHEBI:43474, HO4P, extracellular region
H+CHEBI:15378, H, extracellular region

Catalysed by

nucleoside diphosphate phosphatase activity of NTPDase1:Ca2+,Mg2+ [plasma membrane]EC 3.6.1.6

Literature

Identification and characterization of CD39/vascular ATP diphosphohydrolase J Biol Chem, 1996
Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1 Eur. J. Biochem., 2000
Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8 Purinergic Signal., 2005
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation Nat. Med., 1999
Heterologous cell-cell interactions: thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1) J. Thromb. Haemost., 2003