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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NTPDase7 hydrolyzes nucleoside triphosphates

CTP,GTP,UTP + H2O → CDP,GDP,UDP + Pi + H+

Reactome: R-HSA-8851494
Compartment: endocytic vesicle lumen · endocytic vesicle membrane
Rhea: RHEA:29388, RHEA:64901, RHEA:19670

Inputs

CTP,GTP,UTPR-ALL-8851509, endocytic vesicle lumen
H2OCHEBI:15377, H2O, endocytic vesicle lumen

Outputs

CDP,GDP,UDPR-ALL-8851518, endocytic vesicle lumen
PiCHEBI:43474, HO4P, endocytic vesicle lumen
H+CHEBI:15378, H, endocytic vesicle lumen

Catalysed by

ribonucleoside triphosphate phosphatase activity of NTPDase7:Ca2+ [endocytic vesicle membrane]EC 3.6.1.15

Literature

Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1) J. Biol. Chem., 2001
Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine J. Immunol., 2013