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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)

(d)CMP, TMP, (d)UMP + H2O → (d)C, T, (d)U + Pi

Reactome: R-HSA-109449
Compartment: cytosol
Rhea: RHEA:11081, RHEA:29368, RHEA:29364, RHEA:29360, RHEA:29356

Inputs

(d)CMP, TMP, (d)UMPR-ALL-500347, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

(d)C, T, (d)UR-ALL-500346, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

5'-nucleotidase activity of NT5C3 holoenzyme [cytosol]EC 3.1.3.5

Literature

Human erythrocyte pyrimidine 5'-nucleotidase, PN-I Arch Biochem Biophys, 2002
Pyrimidine nucleotidases from human erythrocyte possess phosphotransferase activities specific for pyrimidine nucleotides FEBS Lett, 1997
Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency Blood, 2001
Pyrimidine 5' nucleotidase deficiency Br J Haematol, 2003