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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP

ADP-D-ribose + H2O → AMP + R5P + 2 H+

Reactome: R-HSA-2393939
Compartment: cytosol
Rhea: RHEA:10413

Inputs

ADP-D-riboseCHEBI:57967, C15H21N5O14P2, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

AMPCHEBI:456215, C10H12N5O7P, cytosol
R5PCHEBI:78346, C5H9O8P, cytosol
2 H+CHEBI:15378, H, cytosol

Catalysed by

ADP-ribose diphosphatase activity of NUDT5 dimer [cytosol]EC 3.6.1.13

Literature

Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity J. Mol. Biol., 2006
Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies J. Mol. Biol., 2008
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein J. Biochem., 2011