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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP

H2O + 2-oxo-ATP(4-) → 2-oxo-AMP(2-) + H+ + PPi

Reactome: R-HSA-2395872
Compartment: cytosol
Rhea: RHEA:67393

Inputs

H2OCHEBI:15377, H2O, cytosol
2-oxo-ATP(4-)CHEBI:172878, C10H12N5O14P3, cytosol

Outputs

2-oxo-AMP(2-)CHEBI:71395, C10H12N5O8P, cytosol
H+CHEBI:15378, H, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

2-hydroxy-ATP hydrolase activity of NUDT1 [cytosol]

Literature

Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP Nucleic Acids Res., 2001
Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria J. Biol. Chem., 1995
Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates J. Biol. Chem., 2004