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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate

H2O + dNTP(4-) → 2'-deoxynucleoside + PPPi + H+

Reactome: R-HSA-8866601
Compartment: nucleoplasm
Rhea: RHEA:46149

Inputs

H2OCHEBI:15377, H2O, nucleoplasm
dNTP(4-)CHEBI:61560, C5H8O12P3R, nucleoplasm

Outputs

2'-deoxynucleosideCHEBI:18274, C5H9O3R, nucleoplasm
PPPiCHEBI:18036, O10P3, nucleoplasm
H+CHEBI:15378, H, nucleoplasm

Catalysed by

triphosphoric monoester hydrolase activity of SAMHD1:Zn2+ tetramer [nucleoplasm]EC 3.1.5

Literature

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells Proc. Natl. Acad. Sci. U.S.A., 2013
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase Nature, 2011
Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase J. Biol. Chem., 2011
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response Nat. Genet., 2009
Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection J. Biol. Chem., 2013
Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase Nat Commun, 2013