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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]

CMP, TMP, UMP + H2O → Cyt-Rib, Thy-dRib, Ura-Rib + Pi

Reactome: R-HSA-109291
Compartment: extracellular region · plasma membrane
Rhea: RHEA:29368, RHEA:11081, RHEA:29360

Inputs

CMP, TMP, UMPR-ALL-500316, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Outputs

Cyt-Rib, Thy-dRib, Ura-RibR-ALL-500318, extracellular region
PiCHEBI:43474, HO4P, extracellular region

Catalysed by

5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane]EC 3.1.3.5

Literature

Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form Eur J Biochem, 1990
Distribution of ecto-5'-nucleotidase on subsets of human T and B lymphocytes as detected by indirect immunofluorescence using goat antibodies J. Immunol., 1987
The importance of having a mentor, and how to find one Gastrointest. Endosc., 2006