NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP

H2O + 2-oxo-dATP(4-) → 2-oxo-dAMP(2-) + H+ + PPi

Reactome

R-HSA-2395818

Compartment

cytosol

Rhea

RHEA:31584

Catalysed by

• 2-hydroxy-dATP hydrolase activity of NUDT1 [cytosol]

Literature

1. The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein J. Biol. Chem., 1999
2. Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria J. Biol. Chem., 1995
3. Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates J. Biol. Chem., 2004
4. Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism Nucleic Acids Res., 1999
5. A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1 J. Biol. Chem., 2002
6. An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress J. Biol. Chem., 2003