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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AMP + H2O => adenosine + orthophosphate [NT5C1B]

AMP + H2O → Ade-Rib + Pi

Reactome: R-HSA-109415
Compartment: cytosol
Rhea: RHEA:29376

Inputs

AMPCHEBI:456215, C10H12N5O7P, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

Ade-RibCHEBI:16335, C10H13N5O4, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

5'-nucleotidase activity of NT5C1B [cytosol]EC 3.1.3.5; UniProt Q96P26

Literature

Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein Biochim Biophys Acta, 2001
Metabolic and functional consequences of cytosolic 5'-nucleotidase-IA overexpression in neonatal rat cardiomyocytes Am J Physiol Heart Circ Physiol, 2003