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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine

3AIB + PYR → L-Ala + 2-methyl-3-oxopropanoate

Reactome: R-HSA-909780
Compartment: mitochondrial matrix
Rhea: RHEA:18394

Inputs

3AIBCHEBI:57731, C4H9NO2, mitochondrial matrix
PYRCHEBI:15361, C3H3O3, mitochondrial matrix

Outputs

L-AlaCHEBI:57972, C3H7NO2, mitochondrial matrix
2-methyl-3-oxopropanoateCHEBI:57700, C4H5O3, mitochondrial matrix

Catalysed by

(R)-3-amino-2-methylpropionate:pyruvate transaminase activity of AGXT2 tetramer [mitochondrial matrix]EC 2.6.1.40

Literature

Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production J Biol Chem, 2010