TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
TMP, UMP, dU5MP, U2MP, U3MP + H2O → Thy-dRib, Ura-Rib, dU + Pi
- Reactome
- R-HSA-109514
- Compartment
- mitochondrial matrix
Inputs
- TMP, UMP, dU5MP, U2MP, U3MPR-ALL-500420, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
Outputs
- Thy-dRib, Ura-Rib, dUR-ALL-500421, mitochondrial matrix
- PiCHEBI:43474, HO4P, mitochondrial matrix
Catalysed by
- 5'-nucleotidase activity of NT5M dimer [mitochondrial matrix]EC 3.1.3.5
Literature
- A deoxynucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease Proc Natl Acad Sci USA, 2000
- Human mitochondrial 5'-deoxynucleotidase. Overproduction in cultured cells and functional aspects J Biol Chem, 2002
- Crystal structure of a human mitochondrial deoxyribonuclease Nt Struct Biol, 2002