Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

XDH dehydrogenates xanthine to form urate

H2O + NAD+ + XAN → H+ + NADH + urate

Reactome: R-HSA-9727349
Compartment: cytosol
Rhea: RHEA:16670

Inputs

H2OCHEBI:15377, H2O, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol
XANCHEBI:17712, C5H4N4O2, cytosol

Outputs

H+CHEBI:15378, H, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
urateCHEBI:17775, C5H4N4O3, cytosol

Catalysed by

xanthine dehydrogenase activity of XDH dimer [cytosol]EC 1.17.1.4

XDH dehydrogenates xanthine to form urate

Inputs

Outputs

Catalysed by

Literature