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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP

8-oxo-dATP(4-) + H2O → 8-oxo-dAMP(2-) + H+ + PPi

Reactome: R-HSA-9731228
Compartment: cytosol
Rhea: RHEA:65397

Inputs

8-oxo-dATP(4-)CHEBI:172871, C10H12N5O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

8-oxo-dAMP(2-)CHEBI:71361, C10H12N5O7P, cytosol
H+CHEBI:15378, H, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

8-oxo-(d)RTP hydrolase activity of NUDT1 [cytosol]EC 3.6.1.9

Literature

The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein J. Biol. Chem., 1999
Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria J. Biol. Chem., 1995
Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates J. Biol. Chem., 2004
Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism Nucleic Acids Res., 1999
An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress J. Biol. Chem., 2003