NTPDase1 hydrolyzes nucleoside triphosphates
NTP + H2O → NDP + Pi + H+
- Reactome
- R-HSA-8850846
- Compartment
- extracellular region · plasma membrane
- Rhea
- RHEA:23681
Inputs
- NTPCHEBI:61557, C5H8O13P3R, extracellular region
- H2OCHEBI:15377, H2O, extracellular region
Outputs
- NDPCHEBI:57930, C5H8O10P2R, extracellular region
- PiCHEBI:43474, HO4P, extracellular region
- H+CHEBI:15378, H, extracellular region
Catalysed by
- ribonucleoside triphosphate phosphatase activity of NTPDase1:Ca2+,Mg2+ [plasma membrane]EC 3.6.1.15
Literature
- Identification and characterization of CD39/vascular ATP diphosphohydrolase J Biol Chem, 1996
- CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness Nat. Med., 2002
- Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1 Eur. J. Biochem., 2000
- Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression J. Exp. Med., 2007
- Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8 Purinergic Signal., 2005
- Impact of ectoenzymes on p2 and p1 receptor signaling Adv. Pharmacol., 2011