NTPDase8 hydrolyzes nucleoside diphosphates
H2O + ADP,GDP,IDP,CDP,TDP,UDP → Pi + AMP,GMP,IMP,CMP,TMP,UMP + H+
- Reactome
- R-HSA-8851550
- Compartment
- extracellular region · plasma membrane
Inputs
- H2OCHEBI:15377, H2O, extracellular region
- ADP,GDP,IDP,CDP,TDP,UDPR-ALL-9726189, extracellular region
Outputs
- PiCHEBI:43474, HO4P, extracellular region
- AMP,GMP,IMP,CMP,TMP,UMPR-ALL-9726186, extracellular region
- H+CHEBI:15378, H, extracellular region
Catalysed by
- nucleoside diphosphate phosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]EC 3.6.1.6
Literature
- Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8 Am. J. Physiol. Gastrointest. Liver Physiol., 2007
- Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase J. Biol. Chem., 2000
- Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8 Biochemistry, 2004