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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP

ADP-Rib + H2O → AMP + R5P + 2 H+

Reactome: R-HSA-2393954
Compartment: mitochondrial matrix
Rhea: RHEA:10413

Inputs

ADP-RibCHEBI:57967, C15H21N5O14P2, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

AMPCHEBI:456215, C10H12N5O7P, mitochondrial matrix
R5PCHEBI:78346, C5H9O8P, mitochondrial matrix
2 H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

ADP-ribose diphosphatase activity of NUDT9 [mitochondrial matrix]EC 3.6.1.13

Literature

NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase J. Biol. Chem., 2003
The crystal structure and mutational analysis of human NUDT9 J. Mol. Biol., 2003