Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NTPDase5 hydrolyzes nucleoside diphosphates

ADP,GDP,CDP,UDP + H2O → AMP,GMP,CMP,UMP + Pi + H+

Reactome: R-HSA-8851356
Compartment: extracellular region
Rhea: RHEA:64877, RHEA:22157, RHEA:64881, RHEA:61437

Inputs

ADP,GDP,CDP,UDPR-ALL-8936165, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Outputs

AMP,GMP,CMP,UMPR-ALL-8851369, extracellular region
PiCHEBI:43474, HO4P, extracellular region
H+CHEBI:15378, H, extracellular region

Catalysed by

nucleoside diphosphate phosphatase activity of NPTDase5:Ca2+,Mg2+ [extracellular region]EC 3.6.1.6

Literature

CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates J. Biol. Chem., 1999
Biochemical characterization of CD39L4 Biochemistry, 2000
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway Cell, 2010
ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells Cold Spring Harb. Symp. Quant. Biol., 2011