Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate

UIBA + H2O + 2 H+ → CO2 + NH4+ + 3AIB

Reactome: R-HSA-73620
Compartment: cytosol
Rhea: RHEA:37340

Inputs

UIBACHEBI:74414, C5H9N2O3, cytosol
H2OCHEBI:15377, H2O, cytosol
2 H+CHEBI:15378, H, cytosol

Outputs

CO2CHEBI:16526, CO2, cytosol
NH4+CHEBI:28938, H4N, cytosol
3AIBCHEBI:57731, C4H9NO2, cytosol

Catalysed by

beta-ureidopropionase activity of UPB1:Zn2+ [cytosol]EC 3.5.1.6

Literature

Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver Methods Enzymol, 2000
beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities Hum Mol Genet, 2004