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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)

(d)GMP, (d)IMP + H2O → Gu-Rib, dG, Ino, dI + Pi

Reactome: R-HSA-74248
Compartment: cytosol
Rhea: RHEA:27715, RHEA:29380, RHEA:27719, RHEA:29384

Inputs

(d)GMP, (d)IMPR-ALL-500120, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

Gu-Rib, dG, Ino, dIR-ALL-500118, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

5'-nucleotidase activity of NT5C2 tetramer [cytosol]EC 3.1.3.5

Literature

High Km soluble 5'-nucleotidase from human placenta J Biol Chem, 1988
Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition J Biol Chem, 2007
Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism J Biol Chem, 2001
Distinct roles for recombinant cytosolic 5'-nucleotidase I and -II in AMP and IMP catabolism in COS-7 and H9c2 rat myoblast cell lines J Biol Chem, 2000
Mammalian 5'-nucleotidases J Biol Chem, 2003