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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NTPDase4 hydrolyzes nucleoside triphosphates

UTP,GTP,CTP,dTTP + H2O → UDP,GDP,CDP,dTDP + Pi + H+

Reactome: R-HSA-8851234
Compartment: Golgi lumen · Golgi membrane
Rhea: RHEA:64901, RHEA:29388, RHEA:19670, RHEA:19014

Inputs

UTP,GTP,CTP,dTTPR-ALL-8851233, Golgi lumen
H2OCHEBI:15377, H2O, Golgi lumen

Outputs

UDP,GDP,CDP,dTDPR-ALL-8851224, Golgi lumen
PiCHEBI:43474, HO4P, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

ribonucleoside triphosphate phosphatase activity of NTPDase4:Ca2+ [Golgi membrane]EC 3.6.1.15

Literature

Golgi localization and functional expression of human uridine diphosphatase J. Biol. Chem., 1998