Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP

AMP, dAMP, GMP, IMP + H2O → Ade-Rib, dA, Gua-Rib, Ino + Pi

Reactome: R-HSA-109278
Compartment: extracellular region · plasma membrane
Rhea: RHEA:29376, RHEA:29372, RHEA:27715, RHEA:27719

Inputs

AMP, dAMP, GMP, IMPR-ALL-500101, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Outputs

Ade-Rib, dA, Gua-Rib, InoR-ALL-500104, extracellular region
PiCHEBI:43474, HO4P, extracellular region

Catalysed by

5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane]EC 3.1.3.5

Literature

Purification of 5'-nucleotidase from human placenta after release from plasma membranes by phosphatidylinositol-specific phospholipase C Biochem Biophys Res Commun, 1987
Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form Eur J Biochem, 1990
5'-nucleotidase: molecular structure and functional aspects Biochem J, 1992