NTPDase6 hydrolyzes nucleoside diphosphates
CDP,GDP,IDP,UDP + H2O → CMP,GMP,IMP,UMP + Pi + H+
- Reactome
- R-HSA-8851396
- Compartment
- extracellular region
- Rhea
- RHEA:22157, RHEA:35208, RHEA:64877, RHEA:64881
Inputs
- CDP,GDP,IDP,UDPR-ALL-8851462, extracellular region
- H2OCHEBI:15377, H2O, extracellular region
Outputs
- CMP,GMP,IMP,UMPR-ALL-8851461, extracellular region
- PiCHEBI:43474, HO4P, extracellular region
- H+CHEBI:15378, H, extracellular region
Catalysed by
- nucleoside diphosphate phosphatase activity of NTPDase6:Ca2+,Mg2+ [extracellular region]EC 3.6.1.6
Literature
- CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart Biochemistry, 2000
- Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function Biochemistry, 2003
- Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2) J. Biol. Chem., 2000