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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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reduction of uracil to form dihydrouracil

Ura + NADPH + H+ → 5,6-Dihydrouracil + NADP+

Reactome
R-HSA-73585
Compartment
cytosol
Rhea
RHEA:18095

Inputs

Outputs

Catalysed by

  • dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]EC 1.3.1.2

Literature

  1. cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria J Biol Chem, 1994