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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

(deoxy)uridine + orthophosphate uracil + (deoxy)ribose 1-phosphate (UPP)

(d)Ura + Pi → Ura + R1P, dRibP

Reactome: R-HSA-74376
Compartment: cytosol
Rhea: RHEA:24389, RHEA:22825

Inputs

(d)UraR-ALL-500430, cytosol
PiCHEBI:43474, HO4P, cytosol

Outputs

UraCHEBI:17568, C4H4N2O2, cytosol
R1P, dRibPR-ALL-500244, cytosol

Catalysed by

uridine phosphorylase activity of UPP1, UPP2 [cytosol]EC 2.4.2.3

Literature

Cloning and expression of human uridine phosphorylase Biochem Biophys Res Commun, 1995
Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy BMC Struct Biol, 2009
Identification of a novel human uridine phosphorylase Biochem Biophys Res Commun, 2003