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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Respiratory electron transport

Transfer of electrons through mitochondrial respiratory complexes and mobile carriers. 47 reactions, from Reactome R-HSA-611105.

  1. Transfer of electrons through the succinate dehydrogenase complexCoQ + SUCCA → FUMA + CoQH2
  2. Electron transfer from reduced cytochrome c to molecular oxygenO2 + 12 H+ + 4 Cytochrome c (reduced) → 2 H2O + 8 H+ + 4 Cytochrome c (oxidised)
  3. Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2NADH + 5 H+ + CoQ → NAD+ + 4 H+ + CoQH2
  4. Electron transfer from ubiquinol to cytochrome c of complex IIICoQ + 2 H+ + 2 Cytochrome c (oxidised) + 2 CoQH2 → 2 CoQ + CoQH2 + 4 H+ + 2 Cytochrome c (reduced)
  5. Reducing equivalents from beta-oxidation of fatty acids transfer to ETFFADH2 + ETF:FAD → ETF:FADH2 + FAD
  6. ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2ETF:FADH2 + CoQ → ETF:FAD + H+ + CoQH2
  7. SLC25A12,13 exchange L-Glu and L-AspL-Asp + L-Glu + H+ → L-Asp + L-Glu + H+
  8. SLC25A11 exchanges 2-OG and MALMAL + 2OG → MAL + 2OG
  9. NUBPL binds 4Fe-4SNUBPL + 4Fe-4S → NUBPL:4Fe-4S
  10. NUBPL transfers 4Fe-4S to Complex I subunitsNDUF subunits + NUBPL:4Fe-4S → NDUF:4Fe-4S subunits + NUBPL
  11. NUBPL transfers 4Fe-4S to NDUFV1, V2NDUFV1 + 2 NUBPL:4Fe-4S + NDUFV2 + FMN → NDUFV1:4Fe-4S:FMN + NDUFV2:4Fe-4S + 2 NUBPL
  12. Intermediate 1 binds HP subcomplex to form Intermediate 2HP subcomplex + Intermediate 1 → Intermediate 2
  13. Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex815kDa complex + FP subcomplex + NDUFS5 → 980kDa complex
  14. Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplexIntermediate 2 + MT-ND1 + NDUFAF5 + NDUFAF6 → 315kDa subcomplex
  15. The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I980kDa complex → Complex I + MCIA complex + NDUFAF2 + NDUFAF3 + NDUFAF4 + NDUFAF5 + NDUFAF6 + NDUFAF7 + TIMMDC1
  16. ND4, ND5 bind the 550kDa complex to form the 815kDa complex550kDa complex + MT-ND4 + MT-ND5 → 815kDa complex
  17. COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplexMCIA complex + MT-ND6 + NDUFB6 + COA1:MT-ND2 + TMEM186:MT-ND3 → 370 kDa subcomplex
  18. The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex315kDa subcomplex + 370 kDa subcomplex → 550kDa complex
  19. IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1IP subcomplex + NDUFAF3 + NDUFAF4 + TIMMDC1 → Intermediate 1
  20. NDUF subunits bind to form the IP subcomplexNDUFA9:FAD + NDUFAF7:NDUFS2:2x4Fe-4S + NDUFS3 + NDUFS7:4Fe-4S + NDUFS8:2x4Fe-4S → IP subcomplex
  21. NDUF subunits bind to form the FP subcomplexNDUFA12 + NDUFAF2 + NDUFS1:2x4Fe-4S + NDUFS4 + NDUFS6 + NDUFV1:4Fe-4S:FMN + NDUFV2:4Fe-4S + NDUFV3 → FP subcomplex
  22. PXLP-K259-GOT1 transaminates 2-OG and L-AspL-Asp + 2OG → OA + L-Glu
  23. GOT2 transaminates OA and L-GluOA + L-Glu → L-Asp + 2OG
  24. MDH2 dimer dehydrogenates MALMAL + NAD+ → OA + NADH + H+
  25. SLC25A18,22 import L-Glu, H+L-Glu + H+ → L-Glu + H+
  26. MDH1 reduces OANADH + OA + H+ → MAL + NAD+
  27. MT-CO1 mRNA is translatedMT-CO1 mRNA → nascent MT-CO1
  28. Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CLMITRAC + nascent MT-CO1 + Mg2+ + PE + cardiolipin → MT-CO1:Mg2+:PE:CL:MITRAC
  29. TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRACTIMM21:COX4:COX5A:COX6C + MT-CO1:Mg2+:PE:CL:MITRAC → MT-CO1:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C
  30. Metallochaperone inserts Cu2+ into MT-CO1MT-CO1:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C + COX17:Cu → MT-CO1:Cu2+:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C + COX17
  31. MT-CO2 mRNA is translatedMT-CO2 mRNA → nascent MT-CO2
  32. MT-CO1 and MT-CO2 complexes associate, installing heme moietiesCOX7B + COX7C + MT-CO1:Cu2+:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C + MT-CO2:Mg2+:CuA + 3 heme A + COX8A,C → holo-MT-CO1,2 complex + TIMM21
  33. Metallochaperone inserts 2Cu2+ into MT-CO22 COX17:Cu + MT-CO2:COX20:TMEM177 → 2 COX17 + MT-CO2:Mg2+:CuA + COX20:TMEM177
  34. MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complexMT-CO3:PE:CL + NDUFA4:CL + COX7A1,2,2L + COX6A:PE + COX6B1,2 + holo-MT-CO1,2 complex → Cytochrome c oxidase + MITRAC
  35. MT-CYB is translatedMT-CYB mRNA + UQCC1:UQCC2:UQCC5:UQCC6 → Intermediate 0
  36. Intermediate 0 binds heme and UQCC3UQCC3 + heme b + Intermediate 0 → Intermediate I
  37. Intermediate I binds second heme, UQCRB, UQCRQUQCRB + UQCRQ + Intermediate I + heme b → Intermediate II + UQCC1:UQCC2:UQCC5:UQCC6
  38. Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRHCYC1:heme c + Intermediate II + UQCRC1 + UQCRC2 + UQCRH, (UQCRHL) → Late core complex monomer + UQCC3
  39. Late core complex dimerizes2 Late core complex monomer → Late core complex dimer
  40. Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.2 UQCR10 + 2 UQCR11 + Late core complex dimer + 2 holo-UQCRFS1(1-274) → Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(1-274)
  41. HCCS inserts heme into cytochrome cheme b + apo-CYCS → Cytochrome c (reduced)
  42. apo-UQCRFS1 binds LYRM7LYRM7 + UQCRFS1(1-274) → UQCRFS1(1-274):LYRM7
  43. 2Fe-2S is inserted in UQCRFS1FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster + UQCRFS1(1-274):LYRM7 → FXN:ISD11:NFS1:ISCU + holo-UQCRFS1(1-274) + LYRM7
  44. COX18 inserts nascent MT-CO2 in COX20:TMEM77Mg2+ + COX20:TMEM177 + nascent MT-CO2 → MT-CO2:COX20:TMEM177
  45. Unknown peptidase cleaves UQCRFS1 subunitDimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(1-274) → Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):Fragments
  46. TTC19 clears UQCRFS1 fragments from Complex IIIDimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):Fragments → Cytochrome c reductase + 2 Unspecified N-terminal UQCRFS1 fragments
  47. MT-ND4 is translatedMT-ND4 mRNA → MT-ND4