Metallochaperone inserts 2Cu2+ into MT-CO2
2 COX17:Cu + MT-CO2:COX20:TMEM177 → 2 COX17 + MT-CO2:Mg2+:CuA + COX20:TMEM177
- Reactome
- R-HSA-9865630
- Compartment
- mitochondrial inner membrane
- Rhea
- None recorded
Inputs
- 2 COX17:CuR-HSA-9865624, mitochondrial intermembrane space
- MT-CO2:COX20:TMEM177R-HSA-9865557, mitochondrial inner membrane
Outputs
- 2 COX17R-HSA-1307788, mitochondrial intermembrane space
- MT-CO2:Mg2+:CuAR-HSA-9865631, mitochondrial inner membrane
- COX20:TMEM177R-HSA-9865587, mitochondrial inner membrane
Catalysed by
- copper chaperone activity of metallochaperone complex [mitochondrial inner membrane]
Literature
- Coordination of metal center biogenesis in human cytochrome c oxidase Nat Commun, 2022
- Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase Mol Biol Cell, 2015
- Role of Copper on Mitochondrial Function and Metabolism Front Mol Biosci, 2021