Electron transfer from reduced cytochrome c to molecular oxygen
O2 + 12 H+ + 4 Cytochrome c (reduced) → 2 H2O + 8 H+ + 4 Cytochrome c (oxidised)
- Reactome
- R-HSA-163214
- Compartment
- mitochondrial inner membrane · mitochondrial intermembrane space · mitochondrial matrix
- Rhea
- RHEA:11437
Inputs
- O2CHEBI:15379, O2, mitochondrial matrix
- 12 H+CHEBI:15378, H, mitochondrial matrix
- 4 Cytochrome c (reduced)R-HSA-352609, mitochondrial inner membrane
Outputs
- 2 H2OCHEBI:15377, H2O, mitochondrial matrix
- 8 H+CHEBI:15378, H, mitochondrial intermembrane space
- 4 Cytochrome c (oxidised)R-HSA-352607, mitochondrial inner membrane
Catalysed by
- cytochrome-c oxidase activity of Cytochrome c oxidase [mitochondrial inner membrane]EC 7.1.1.9
Literature
- Energy transduction by cytochrome complexes in mitochondrial and bacterial Annu Rev Biochem, 1994
- Structures and proton-pumping strategies of mitochondrial respiratory Annu Rev Biophys Biomol Struct, 2001
- Proton pump coupled to cytochrome c oxidase in mitochondria Nature, 1977
- Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process Am. J. Physiol., Cell Physiol., 2006
- Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core Biochim. Biophys. Acta, 2012
- Biogenesis of eukaryotic cytochrome c oxidase Physiol Res, 2006