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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC25A18,22 import L-Glu, H+

L-Glu + H+ → L-Glu + H+

Reactome: R-HSA-8875623
Compartment: cytosol · mitochondrial inner membrane · mitochondrial matrix
Rhea: RHEA:70955, RHEA:70957

Inputs

L-GluCHEBI:29985, C5H8NO4, cytosol
H+CHEBI:15378, H, cytosol

Outputs

L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

amino acid:proton symporter activity of SLC25A18,A22 [mitochondrial inner membrane]

Literature

Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms J. Biol. Chem., 2002
Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsy Am. J. Hum. Genet., 2005
Neonatal Seizures: An Overview of Genetic Causes and Treatment Options Brain Sci, 2021