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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1

IP subcomplex + NDUFAF3 + NDUFAF4 + TIMMDC1 → Intermediate 1

Reactome: R-HSA-6799203
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: None recorded

Inputs

IP subcomplexR-HSA-5689699, mitochondrial matrix
NDUFAF3R-HSA-5689126, mitochondrial inner membrane
NDUFAF4R-HSA-5689124, mitochondrial inner membrane
TIMMDC1R-HSA-5689720, mitochondrial inner membrane

Outputs

Intermediate 1R-HSA-6788529, mitochondrial inner membrane

Literature

Assembly factors for the membrane arm of human complex I Proc. Natl. Acad. Sci. U.S.A., 2013
Assembly factors of human mitochondrial complex I and their defects in disease IUBMB Life, 2010
MidA is a putative methyltransferase that is required for mitochondrial complex I function J. Cell. Sci., 2010
Understanding mitochondrial complex I assembly in health and disease Biochim. Biophys. Acta, 2012
Mutations in the complex I NDUFS2 gene of patients with cardiomyopathy and encephalomyopathy Ann. Neurol., 2001