Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL
MITRAC + nascent MT-CO1 + Mg2+ + PE + cardiolipin → MT-CO1:Mg2+:PE:CL:MITRAC
- Reactome
- R-HSA-9865350
- Compartment
- mitochondrial inner membrane
- Rhea
- None recorded
Inputs
- MITRACR-HSA-9865338, mitochondrial inner membrane
- nascent MT-CO1R-HSA-164314, mitochondrial inner membrane
- Mg2+CHEBI:18420, Mg, mitochondrial matrix
- PECHEBI:57613, C7H12NO8PR2, mitochondrial inner membrane
- cardiolipinCHEBI:28494, C13H18O17P2R4, mitochondrial inner membrane
Outputs
- MT-CO1:Mg2+:PE:CL:MITRACR-HSA-9865433, mitochondrial inner membrane
Literature
- MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation Cell, 2012
- MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly Cell Rep, 2015
- A CMC1 -knockout reveals translation-independent control of human mitochondrial complex IV biogenesis EMBO Rep, 2017
- SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome Nat Genet, 1998