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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Metallochaperone inserts Cu2+ into MT-CO1

MT-CO1:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C + COX17:Cu → MT-CO1:Cu2+:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6C + COX17

Reactome
R-HSA-9865449
Compartment
mitochondrial inner membrane
Rhea
None recorded

Inputs

  • MT-CO1:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6CR-HSA-9865410, mitochondrial inner membrane
  • COX17:CuR-HSA-9865624, mitochondrial intermembrane space

Outputs

  • MT-CO1:Cu2+:Mg2+:PE:CL:MITRAC:TIMM21:COX4:COX5A:COX6CR-HSA-9865438, mitochondrial inner membrane
  • COX17R-HSA-1307788, mitochondrial intermembrane space

Catalysed by

  • copper chaperone activity of metallochaperone complex [mitochondrial inner membrane]

Literature

  1. Coordination of metal center biogenesis in human cytochrome c oxidase Nat Commun, 2022
  2. COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux Mol Biol Cell, 2013
  3. Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase Mol Biol Cell, 2015
  4. Role of Copper on Mitochondrial Function and Metabolism Front Mol Biosci, 2021