Transfer of electrons through the succinate dehydrogenase complex
CoQ + SUCCA → FUMA + CoQH2
- Reactome
- R-HSA-163213
- Compartment
- mitochondrial inner membrane
- Rhea
- RHEA:13714
Inputs
- CoQCHEBI:46245, C59H90O4, mitochondrial inner membrane
- SUCCACHEBI:30031, C4H4O4, mitochondrial matrix
Outputs
- FUMACHEBI:29806, C4H2O4, mitochondrial matrix
- CoQH2CHEBI:64183, C59H92O4, mitochondrial inner membrane
Catalysed by
- succinate dehydrogenase (quinone) activity of SDH complex [mitochondrial inner membrane]EC 1.3.5.1
Literature
- The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase Cell Metab., 2013
- Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis Proc. Natl. Acad. Sci. U.S.A., 2013
- Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells Oncotarget, 2014