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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NDUF subunits bind to form the IP subcomplex

NDUFA9:FAD + NDUFAF7:NDUFS2:2x4Fe-4S + NDUFS3 + NDUFS7:4Fe-4S + NDUFS8:2x4Fe-4S → IP subcomplex

Reactome: R-HSA-6800868
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

NDUFA9:FADR-HSA-164289, mitochondrial matrix
NDUFAF7:NDUFS2:2x4Fe-4SR-HSA-164288, mitochondrial matrix
NDUFS3R-HSA-163927, mitochondrial matrix
NDUFS7:4Fe-4SR-HSA-164293, mitochondrial matrix
NDUFS8:2x4Fe-4SR-HSA-164295, mitochondrial matrix

Outputs

IP subcomplexR-HSA-5689699, mitochondrial matrix

Literature

Assembly factors of human mitochondrial complex I and their defects in disease IUBMB Life, 2010
Assembly factors for the membrane arm of human complex I Proc. Natl. Acad. Sci. U.S.A., 2013