Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MDH1 reduces OA

NADH + OA + H+ → MAL + NAD+

Reactome: R-HSA-9856871
Compartment: cytosol
Rhea: RHEA:21434

Inputs

NADHCHEBI:57945, C21H27N7O14P2, cytosol
OACHEBI:16452, C4H2O5, cytosol
H+CHEBI:15378, H, cytosol

Outputs

MALCHEBI:15589, C4H4O5, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Catalysed by

L-malate dehydrogenase (NAD+) activity of MDH1 dimer [cytosol]EC 1.1.1.37

Literature

Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution Biochemistry, 1989
Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes Ann Hum Genet, 1988
Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1) J Cell Biochem, 2005
Cytosolic malate dehydrogenase regulates senescence in human fibroblasts Biogerontology, 2012
MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy Hum Genet, 2019
Structural Characterization of the Human Cytosolic Malate Dehydrogenase I ACS Omega, 2022