MDH2 dimer dehydrogenates MAL
MAL + NAD+ → OA + NADH + H+
- Reactome
- R-HSA-70979
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:21433
Inputs
- MALCHEBI:15589, C4H4O5, mitochondrial matrix
- NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
Outputs
- OACHEBI:16452, C4H2O5, mitochondrial matrix
- NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Catalysed by
- L-malate dehydrogenase (NAD+) activity of MDH2 dimer [mitochondrial matrix]EC 1.1.1.37
Literature
- An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates J Biochem Biophys Methods, 2006
- Aggregation states of mitochondrial malate dehydrogenase Protein Sci, 1998
- Structural Comparison of hMDH2 Complexed with Natural Substrates and Cofactors: The Importance of Phosphate Binding for Active Conformation and Catalysis Biomolecules, 2022
- Malate dehydrogenase 2 deficiency is an emerging cause of pediatric epileptic encephalopathy with a recognizable biochemical signature Mol Genet Metab Rep, 2022
- Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth Sci China Life Sci, 2022