The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
980kDa complex → Complex I + MCIA complex + NDUFAF2 + NDUFAF3 + NDUFAF4 + NDUFAF5 + NDUFAF6 + NDUFAF7 + TIMMDC1
- Reactome
- R-HSA-6799196
- Compartment
- mitochondrial inner membrane
- Rhea
- None recorded
Inputs
- 980kDa complexR-HSA-6799183, mitochondrial inner membrane
Outputs
- Complex IR-HSA-6799192, mitochondrial inner membrane
- MCIA complexR-HSA-5689052, mitochondrial inner membrane
- NDUFAF2R-HSA-5689129, mitochondrial inner membrane
- NDUFAF3R-HSA-5689126, mitochondrial inner membrane
- NDUFAF4R-HSA-5689124, mitochondrial inner membrane
- NDUFAF5R-HSA-5689127, mitochondrial inner membrane
- NDUFAF6R-HSA-5689130, mitochondrial inner membrane
- NDUFAF7R-HSA-6788525, mitochondrial matrix
- TIMMDC1R-HSA-5689720, mitochondrial inner membrane
Literature
- Assembly factors for the membrane arm of human complex I Proc. Natl. Acad. Sci. U.S.A., 2013
- Assembly factors of human mitochondrial complex I and their defects in disease IUBMB Life, 2010