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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2

ETF:FADH2 + CoQ → ETF:FAD + H+ + CoQH2

Reactome: R-HSA-169270
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: RHEA:24053

Inputs

ETF:FADH2R-HSA-169268, mitochondrial matrix
CoQCHEBI:46245, C59H90O4, mitochondrial inner membrane

Outputs

ETF:FADR-HSA-169267, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix
CoQH2CHEBI:64183, C59H92O4, mitochondrial inner membrane

Catalysed by

electron-transferring-flavoprotein dehydrogenase activity of ETFDH [mitochondrial inner membrane]EC 1.5.5.1; UniProt Q16134

Literature

Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria FEBS Lett., 1992
Studies on the mechanisms of oxidative phosphorylation. IX. Effect of cytochrome c on energy-linked processes J. Biol. Chem., 1966