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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUBPL transfers 4Fe-4S to NDUFV1, V2

NDUFV1 + 2 NUBPL:4Fe-4S + NDUFV2 + FMN → NDUFV1:4Fe-4S:FMN + NDUFV2:4Fe-4S + 2 NUBPL

Reactome: R-HSA-6788556
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: None recorded

Inputs

NDUFV1R-HSA-163926, mitochondrial inner membrane
2 NUBPL:4Fe-4SR-HSA-5690007, mitochondrial matrix
NDUFV2R-HSA-163939, mitochondrial inner membrane
FMNCHEBI:58210, C17H18N4O9P, mitochondrial matrix

Outputs

NDUFV1:4Fe-4S:FMNR-HSA-6788516, mitochondrial inner membrane
NDUFV2:4Fe-4SR-HSA-6788524, mitochondrial inner membrane
2 NUBPLR-HSA-5689133, mitochondrial matrix

Literature

Assembly factors for the membrane arm of human complex I Proc. Natl. Acad. Sci. U.S.A., 2013
Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation? Biochem. Biophys. Res. Commun., 1998