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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Unknown peptidase cleaves UQCRFS1 subunit

Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(1-274) → Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):Fragments

Reactome: R-HSA-9906017
Compartment: mitochondrial inner membrane
Rhea: None recorded

Inputs

Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(1-274)R-HSA-9906021, mitochondrial inner membrane

Outputs

Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):FragmentsR-HSA-9906014, mitochondrial inner membrane

Catalysed by

endopeptidase activity of Unidentified protease [mitochondrial inner membrane]

Literature

TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III Mol Cell, 2017
Mitochondrial complex III Rieske Fe-S protein processing and assembly Cell Cycle, 2018