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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GOT2 transaminates OA and L-Glu

OA + L-Glu → L-Asp + 2OG

Reactome: R-HSA-70613
Compartment: mitochondrial matrix
Rhea: RHEA:21826

Inputs

OACHEBI:16452, C4H2O5, mitochondrial matrix
L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix

Outputs

L-AspCHEBI:29991, C4H6NO4, mitochondrial matrix
2OGCHEBI:16810, C5H4O5, mitochondrial matrix

Catalysed by

L-aspartate:2-oxoglutarate transaminase activity of GOT2 dimer [mitochondrial matrix]EC 2.6.1.1

Literature

The primary structure of mitochondrial aspartate aminotransferase from human heart Biochim Biophys Acta, 1985
Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy Am J Hum Genet, 2019
Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase Biosci Trends, 2016