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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Intermediate 0 binds heme and UQCC3

UQCC3 + heme b + Intermediate 0 → Intermediate I

Reactome: R-HSA-9866061
Compartment: mitochondrial inner membrane
Rhea: None recorded

Inputs

UQCC3R-HSA-9866062, mitochondrial inner membrane
heme bCHEBI:26355, C34H32FeN4O4, mitochondrial inner membrane
Intermediate 0R-HSA-9865914, mitochondrial inner membrane

Outputs

Intermediate IR-HSA-9866058, mitochondrial inner membrane

Literature

C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization Mol Cell Biol, 2015
Biogenesis of the bc 1 Complex of the Mitochondrial Respiratory Chain J Mol Biol, 2018
Assembly of the Multi-Subunit Cytochrome bc 1 Complex in the Yeast Saccharomyces cerevisiae Int J Mol Sci, 2022
A mutation in the human CBP4 ortholog UQCC3 impairs complex III assembly, activity and cytochrome b stability Hum Mol Genet, 2014