COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
MCIA complex + MT-ND6 + NDUFB6 + COA1:MT-ND2 + TMEM186:MT-ND3 → 370 kDa subcomplex
- Reactome
- R-HSA-6799199
- Compartment
- mitochondrial inner membrane
- Rhea
- None recorded
Inputs
- MCIA complexR-HSA-5689052, mitochondrial inner membrane
- MT-ND6R-HSA-60569, mitochondrial inner membrane
- NDUFB6R-HSA-59938, mitochondrial inner membrane
- COA1:MT-ND2R-HSA-9708004, mitochondrial inner membrane
- TMEM186:MT-ND3R-HSA-9708002, mitochondrial inner membrane
Outputs
- 370 kDa subcomplexR-HSA-6799190, mitochondrial inner membrane
Literature
- Assembly factors for the membrane arm of human complex I Proc. Natl. Acad. Sci. U.S.A., 2013
- Assembly factors of human mitochondrial complex I and their defects in disease IUBMB Life, 2010
- Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I Cell Rep, 2020
- FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy Hum Mol Genet, 2010
- Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I Hum Mol Genet, 2015
- Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module Proc Natl Acad Sci U S A, 2022