MT-CO1 mRNA is translated

MT-CO1 mRNA → nascent MT-CO1

Reactome

R-HSA-9865309

Compartment

mitochondrial inner membrane · mitochondrial matrix

Rhea

None recorded

Literature

1. Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome Nat Genet, 2009
2. PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis Free Radic Biol Med, 2023
3. Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein Cell, 2016
4. MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase Cell Rep, 2017
5. Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors Elife, 2021