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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex

815kDa complex + FP subcomplex + NDUFS5 → 980kDa complex

Reactome: R-HSA-6799179
Compartment: mitochondrial inner membrane
Rhea: None recorded

Inputs

815kDa complexR-HSA-6799187, mitochondrial inner membrane
FP subcomplexR-HSA-5689686, mitochondrial inner membrane
NDUFS5R-HSA-60226, mitochondrial inner membrane

Outputs

980kDa complexR-HSA-6799183, mitochondrial inner membrane

Literature

Understanding mitochondrial complex I assembly in health and disease Biochim. Biophys. Acta, 2012