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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC25A11 exchanges 2-OG and MAL

MAL + 2OG → MAL + 2OG

Reactome: R-HSA-376851
Compartment: cytosol · mitochondrial inner membrane · mitochondrial matrix
Rhea: RHEA:71587, RHEA:71589

Inputs

MALCHEBI:15589, C4H4O5, cytosol
2OGCHEBI:16810, C5H4O5, mitochondrial matrix

Outputs

MALCHEBI:15589, C4H4O5, mitochondrial matrix
2OGCHEBI:16810, C5H4O5, cytosol

Catalysed by

oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]

Literature