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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUBPL binds 4Fe-4S

NUBPL + 4Fe-4S → NUBPL:4Fe-4S

Reactome: R-HSA-5690023
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

NUBPLR-HSA-5689133, mitochondrial matrix
4Fe-4SR-ALL-169274, mitochondrial matrix

Outputs

NUBPL:4Fe-4SR-HSA-5690007, mitochondrial matrix

Literature

Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I Mol. Cell. Biol., 2009
NUBPL mutations in patients with complex I deficiency and a distinct MRI pattern Neurology, 2013